Butabarbital decreases outcomes of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may possibly decrease sufentanil degrees and efficacy, possibly precipitating withdrawal syndrome in people that have made Actual physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 ind... https://stevee542inp5.wikidank.com/user