Limb-threatening or crucial limb ischemia (CLI) is manifested by Persistent (in excess of two weeks) ischemic rest discomfort, ischemic wounds or tissue reduction, or gangrene in one or each legs. Ischemic relaxation pain ordinarily happens shortly right after falling asleep; the affected individual is awakened by burning pain or numbness https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/