Limb-threatening or significant limb ischemia (CLI) is manifested by chronic (much more than two weeks) ischemic rest suffering, ischemic wounds or tissue reduction, or gangrene in one or equally legs. Ischemic rest soreness usually takes place before long following falling asleep; the patient is awakened by burning soreness or numbness https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/