. this sort of experiments are called mutation accumulation (MA) experiments (Elena and Lenski 2003; Lind and Andersson 2008; Brockhurst et al. 2010). It is now doable to stick to up MA experiments with entire-genome https://minibookmarks.com/story18109048/how-much-you-need-to-expect-you-ll-pay-for-a-good-supplement-protocol