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In a earlier study20 that population PK modeling was formulated with two-compartment design of the two parent and metabolite, plus the parameter such as CL/File Flipping the way from the R2 and R1 bonds results in the R- and S- enantiomers of O-Desmethyltramadol. O-DMST is nearly just like tramadol, https://hemalchem.com/product/o-dsmt/

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